Fender Replacement
 

I have a 92 S-10 Blazer 4X4 V6 that is mechanically sound but all front Fenders ( inner and outer, passenger and drivers side ) are completely rotten.
I have done some mechanical and electrical work on cars over the years ( much to the annoyance of my wife ) but very little bodywork so any information on replacing these Fenders will be appreciated.

They'll unbolt relatively easily. Remove all of the bolts found inside the wheel well between the inner fender and the outer fender. Then remove the bolts up at the radiator core support (you'll likely have to remove the headlight trim rings to get at some of the bolts. Then remove the bolts at the bottom of the fender under the firewall. I believe you will have to remove the trim panel at the back of the hood under the windshield wipers. Lastly, remove the bolt at the top of the firewall and it should come right off.

Thanks for the info.
When installing the new Inner and/or Outer Fenders, are there any tricks, tools or other materials needed ( gaskets etc )?

You'll have to redo the shim stack to properly align the body lines, but other than that, not really.

If you can, try to find some original sheetmetal. The aftermarket parts can cause you fits to get things aligned. They're thinner sheetmetal as well.