Is there a difference in wheels...
 

From 2wd, and 4wd S-10 blazers? Would a wheel from a 2wd work on a 4wd?

I'm assuming you mean rim...and if so, then rims are all based on bolt pattern. All Blazers have the same bolt pattern (as far as I know) so they can be interchangeable.

The difference between a 2wd rim and a 4wd rim is the back space. 2wd rims are 4" back space while the 4wd rims are 6" back space. Yes you can put 2wd rims on a 4wd but the rim is going to stick out past the fenders roughly 2". Look up Georgesblazah, there are pictures of his truck with 2wd S10 ZQ8 wheels.

Found a set of 2wd alloys from a S-10 pickup 98+. Now that I know the back spacing is difference I may just look for a set of stock 4wd wheels.

Learn something new everyday lol...I didn't even think about back spacing.

Corvette wheel on Xtreme
 

Any one knows if the 11" Corvette wheels can feet on my 01 blazer xtreme using spacers, I been told that I can use 10" with no problems (using spacers) But it I can fit the 11" will be perfect.

https://blazerforum.com/forum/tires-wheels-13/corvette-wheels-24581/ << read post #2