Is it a bad thing to have only one misfire I got a code for misfire on number 4 and somebody said it might be a bad thing because of the spider injection 1996 Blazer LT

 

How do know it is a fuel issue? You could have a bad spark plug wire.

Either way I cannot think it a good thing.

 

doing plugs wires and cap hopefully that will solve the problem and it's not a poppet

 

But if you have to replace the spider, it is not the worst job as only the upper part of the intake has to be removed. Also, it is possible to do an upgrade to the later design while you are at it.