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I am going to hope that you ment to type 35's. If that is the case then yes you can fit them with some trimming. If you did mean 45's then there is absolutly no way.
45's or 35's? Because this truck (my friends 72 f250) below has 44's so 45's would be slightly bigger than that. You'd need alot of lift to fit tires that size on a blazer.
Damm 45's???? Exactly you need a solid front axel and hack your truck to death to make the clear like the photo above. Get a full size truck if you want to run 45's.